带有背光和曼陀罗的佛陀立像，犍陀罗地区 #Archaeology# #AncientArt#
Title: Buddha with Radiate Halo and Mandorla
Date: 6th century
Culture: Pakistan (ancient region of Gandhara)
Medium: Brass
Dimensions: H. 11 1/2 in. (29.2 cm); W. 5 1/2 in. (14 cm)
Classification: Sculpture
Credit Line: Edith Perry Chapman Fund, 1948
Accession Number: 48.66a, b
This image was likely used for personal veneration. The Buddha wears a typical Gandharan-style robe while his hair is reminiscent of images from Swat and Kashmir. Although the combined radiate halo and mandorla appears in Gandhara, this exact motif is found at the Afghan site of Bamiyan. The portability of such Buddhist images made them important vehicles for disseminating this hybrid Gandharan style. https://t.cn/A66atvhj
Title: Buddha with Radiate Halo and Mandorla
Date: 6th century
Culture: Pakistan (ancient region of Gandhara)
Medium: Brass
Dimensions: H. 11 1/2 in. (29.2 cm); W. 5 1/2 in. (14 cm)
Classification: Sculpture
Credit Line: Edith Perry Chapman Fund, 1948
Accession Number: 48.66a, b
This image was likely used for personal veneration. The Buddha wears a typical Gandharan-style robe while his hair is reminiscent of images from Swat and Kashmir. Although the combined radiate halo and mandorla appears in Gandhara, this exact motif is found at the Afghan site of Bamiyan. The portability of such Buddhist images made them important vehicles for disseminating this hybrid Gandharan style. https://t.cn/A66atvhj
#SYNLETT# We report the design and synthesis of a strong, chiral, enantiopure sulfoxide-based C–H acid. Single-crystal X-ray analysis confirms the proposed structure and its absolute configuration. The new motif shows a high acidity and activity in Brønsted and Lewis acid catalyzed transformations. So far, only little to no enantioselectivities were achieved.
阅读全文：A Chiral Sulfoxide-Based C–H Acid https://t.cn/A66xOCFw
阅读全文：A Chiral Sulfoxide-Based C–H Acid https://t.cn/A66xOCFw
肺癌是最常见的恶性肿瘤之一，也是全球癌症相关死亡的主要原因。所有肺癌病例中约有85％是非小细胞肺癌（NSCLC），这种病很难治愈。尽管在诊断方法，手术，化学疗法和放射疗法方面取得了很大进展，但NSCLC患者的5年总生存率仍然令人沮丧。因此，迫切需要发现更有效的NSCLC治疗剂。
过去十年的研究表明，木犀草素（3'，4'，5,7-四羟基黄酮）是一种在许多食品和绿色植物中发现的黄酮类化合物，具有令人鼓舞的抗癌作用[9]。实验证据表明，木犀草素（LTL）通过在体外作用于几种分子靶标来抑制肺癌细胞的细胞增殖或诱导细胞凋亡。例如，在人类NSCLC A549细胞中，LTL可通过磷酸化c-Jun N末端激酶（JNK）和抑制核转录因子κB（NF-κB）易位来明显抑制细胞生长并激活线粒体凋亡途径[10]。此外，据报道，LTL通过激活丝裂原活化蛋白激酶/细胞外调节蛋白激酶（MEK / ERK）信号通路，在A549细胞中诱导细胞凋亡和抑制细胞迁移。 LTL还可通过抑制趋化因子（CeC motif）配体2（CCL2）的表达直接抑制Lewis肺癌细胞的增殖和迁移。然而，尽管已经鉴定了许多靶标，但是LTL是否在体内抑制NSCLC恶性行为中起作用仍然不清楚，并且其潜在的机制，特别是微小RNA（miRNA）的参与仍然知之甚少。美国官网订购www.Lutimax.com
过去十年的研究表明，木犀草素（3'，4'，5,7-四羟基黄酮）是一种在许多食品和绿色植物中发现的黄酮类化合物，具有令人鼓舞的抗癌作用[9]。实验证据表明，木犀草素（LTL）通过在体外作用于几种分子靶标来抑制肺癌细胞的细胞增殖或诱导细胞凋亡。例如，在人类NSCLC A549细胞中，LTL可通过磷酸化c-Jun N末端激酶（JNK）和抑制核转录因子κB（NF-κB）易位来明显抑制细胞生长并激活线粒体凋亡途径[10]。此外，据报道，LTL通过激活丝裂原活化蛋白激酶/细胞外调节蛋白激酶（MEK / ERK）信号通路，在A549细胞中诱导细胞凋亡和抑制细胞迁移。 LTL还可通过抑制趋化因子（CeC motif）配体2（CCL2）的表达直接抑制Lewis肺癌细胞的增殖和迁移。然而，尽管已经鉴定了许多靶标，但是LTL是否在体内抑制NSCLC恶性行为中起作用仍然不清楚，并且其潜在的机制，特别是微小RNA（miRNA）的参与仍然知之甚少。美国官网订购www.Lutimax.com
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