帕纳替尼/普纳替尼(PONATINIB)能否一线治疗白血病患者？
帕纳替尼一线治疗CML的疗效研究：帕纳替尼是一种抗肿瘤药物。适用于成人CML((CML)，“费城染色体阳性”(Ph+)的急性淋巴细胞性白血病(ALL)的治疗。对于达沙替尼或尼洛替尼治疗无效，或者无法耐受达沙替尼或尼洛替尼，或者伊马替尼后续治疗不合适的患者，主要用来治疗。还可以用来治疗基因突变的病人(“T315I突变”)，这种突变会使病人对伊马替尼、达沙替尼或尼洛替尼产生抗性。
根据第二阶段的研究发现，酪氨酸激酶抑制剂(TKI)帕纳替尼在大多数新诊断为慢性期CML的病人中能产生完全的细胞遗传学缓解。但是这种药物血管的副作用提示，应该首先考虑使用其他一线治疗药物。25-30%的患者对TKI一线疗法具有耐药性。这样的治疗能改善病人的预后，避免或防止TKI耐药的发生。Panamini是第三代酪氨酸激酶抑制剂，它不仅能抑制BCR-ABL1激酶的活性，而且它的药物安全性也成为一个隐患。
帕纳替尼一线治疗CML的疗效研究：帕纳替尼是一种抗肿瘤药物。适用于成人CML((CML)，“费城染色体阳性”(Ph+)的急性淋巴细胞性白血病(ALL)的治疗。对于达沙替尼或尼洛替尼治疗无效，或者无法耐受达沙替尼或尼洛替尼，或者伊马替尼后续治疗不合适的患者，主要用来治疗。还可以用来治疗基因突变的病人(“T315I突变”)，这种突变会使病人对伊马替尼、达沙替尼或尼洛替尼产生抗性。
根据第二阶段的研究发现，酪氨酸激酶抑制剂(TKI)帕纳替尼在大多数新诊断为慢性期CML的病人中能产生完全的细胞遗传学缓解。但是这种药物血管的副作用提示，应该首先考虑使用其他一线治疗药物。25-30%的患者对TKI一线疗法具有耐药性。这样的治疗能改善病人的预后，避免或防止TKI耐药的发生。Panamini是第三代酪氨酸激酶抑制剂，它不仅能抑制BCR-ABL1激酶的活性，而且它的药物安全性也成为一个隐患。
Article:
Topological modes in a laser cavity through exceptional state transfer
10.1126/science.abl6571
abstract:
"Shaping the light emission characteristics of laser systems is of great importance in various areas of science and technology. In a typical lasing arrangement, the transverse spatial profile of a laser mode tends to remain self-similar throughout the entire cavity. Going beyond this paradigm, we demonstrate here how to shape a spatially evolving mode such that it faithfully settles into a pair of bi-orthogonal states at the two opposing facets of a laser cavity. This was achieved by purposely
||designing a structure that allows the lasing mode to encircle a non-Hermitian exceptional point while deliberately avoiding non-adiabatic jumps.||
The resulting state transfer reflects the unique topology of the associated Riemann surfaces associated with this singularity. Our approach provides a route to developing versatile mode-selective active devices and sheds light on the interesting topological features of exceptional points."
Topological modes in a laser cavity through exceptional state transfer
10.1126/science.abl6571
abstract:
"Shaping the light emission characteristics of laser systems is of great importance in various areas of science and technology. In a typical lasing arrangement, the transverse spatial profile of a laser mode tends to remain self-similar throughout the entire cavity. Going beyond this paradigm, we demonstrate here how to shape a spatially evolving mode such that it faithfully settles into a pair of bi-orthogonal states at the two opposing facets of a laser cavity. This was achieved by purposely
||designing a structure that allows the lasing mode to encircle a non-Hermitian exceptional point while deliberately avoiding non-adiabatic jumps.||
The resulting state transfer reflects the unique topology of the associated Riemann surfaces associated with this singularity. Our approach provides a route to developing versatile mode-selective active devices and sheds light on the interesting topological features of exceptional points."
29.67元34.62倍PE发行的联盛化学35.00元开盘首日上涨30.74％报收38.79元，换手率71.71％。这家浙江省临海市企业主营医药中间体、农药中间体、电子化学品及化工溶剂为主的精细化学品，主要产品包括γ-丁内酯(GBL)、α-乙酰基-γ-丁内酯(ABL)、N-甲基吡咯烷酮(NMP)、4-氯-2-三氟乙酰基苯胺水合物盐酸盐(E2)、环丙甲酮(CPMK)、异丙醇(IPA)、1,2-己二醇(HDO)，生产过程中的副产品主要有氢气、乙醇、香蕉水、磷酸盐、氯化锂水溶液、2-甲基-4,5-二氢呋喃等。在BDO产业链产品制造领域积累了丰富的生产经验。去年营收8.33亿，归属净利润8852万同比下降9.43％。一季报2350万元，同比下降19.10%。三高型小盘中价化学制品/化学原料题材股基本面普通毛利率21.60％，题材类似本立科技、江天化学、大洋生物，上市首日41.89亿总市值对应47.33倍PE在化学原料板块处于较高水位，医药农药中间体企业，化工周期类股经营稳定优势不明显，短期估值较高，中期略作关注。#次新股该怎么做[超话]#$联盛化学 sz301212$
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