这类皮肤炎症如何治疗?科学岛团队有新发现
近日,中科院合肥物质科学研究院等离子体所倪国华研究员课题组联合安徽医科大学副教授王栋在大气压冷等离子体(CAP)治疗特异性皮炎领域取得新的进展。目前该成果在线发表于国际知名学术期刊Frontiers in Immunology。
特异性皮炎(AD)是一种具有慢性、瘙痒性、炎症性特点的皮肤病,终生患病率高达20%,其临床表现为局部皮肤的红斑、丘疹、丘疱疹、剧烈瘙痒等,外用激素类药物是其主要治疗手段,虽有很好的疗效,但副作用也非常明显,在提高治疗有效性的同时,减少甚至避免副作用,仍是临床面临的一个挑战。
研究团队利用自主研发的等离子体设备,将CAP引入AD小鼠病灶处,结果显示,CAP能够减轻二硝基氟苯(DNFB)所引起的皮肤炎症,主要表现为CAP治疗后AD小鼠病灶处皮肤红斑、丘疹明显减少,因炎症所引起异常的皮层增厚得到改善,紊乱的炎症指标得到恢复。
同时,针对治疗机制的研究发现,CAP诱导了缺氧诱导因子-1(HIF-1)在细胞内的表达增加,并与中脑星形细胞源性神经营养因子(MANF)基因的启动子区域结合,增强了MANF的转录表达,通过与NF-κB/p65的关键亚基相互作用抑制炎症。研究团队首次提出了HIF-1参与调节MANF的转录水平表达,并以HIF-1/MANF轴治疗AD。基于上述小鼠试验研究结果,展现出CAP在治疗AD方面具有非常好的医学应用前景。(记者 葛清政)
近日,中科院合肥物质科学研究院等离子体所倪国华研究员课题组联合安徽医科大学副教授王栋在大气压冷等离子体(CAP)治疗特异性皮炎领域取得新的进展。目前该成果在线发表于国际知名学术期刊Frontiers in Immunology。
特异性皮炎(AD)是一种具有慢性、瘙痒性、炎症性特点的皮肤病,终生患病率高达20%,其临床表现为局部皮肤的红斑、丘疹、丘疱疹、剧烈瘙痒等,外用激素类药物是其主要治疗手段,虽有很好的疗效,但副作用也非常明显,在提高治疗有效性的同时,减少甚至避免副作用,仍是临床面临的一个挑战。
研究团队利用自主研发的等离子体设备,将CAP引入AD小鼠病灶处,结果显示,CAP能够减轻二硝基氟苯(DNFB)所引起的皮肤炎症,主要表现为CAP治疗后AD小鼠病灶处皮肤红斑、丘疹明显减少,因炎症所引起异常的皮层增厚得到改善,紊乱的炎症指标得到恢复。
同时,针对治疗机制的研究发现,CAP诱导了缺氧诱导因子-1(HIF-1)在细胞内的表达增加,并与中脑星形细胞源性神经营养因子(MANF)基因的启动子区域结合,增强了MANF的转录表达,通过与NF-κB/p65的关键亚基相互作用抑制炎症。研究团队首次提出了HIF-1参与调节MANF的转录水平表达,并以HIF-1/MANF轴治疗AD。基于上述小鼠试验研究结果,展现出CAP在治疗AD方面具有非常好的医学应用前景。(记者 葛清政)
女神密涅瓦头像,罗马帝国,1世纪 #Archaeology# #AncientArt#
Rest assured that I paid due deference to Sulis Minerva... Domitian would be so proud of me! #Roman# #Goddess#
Gilt bronze head of Sulis Minerva, discovered at Bath in 1727: perhaps ca. Late 1st Century AD.
https://t.cn/A6aEWddZ
Rest assured that I paid due deference to Sulis Minerva... Domitian would be so proud of me! #Roman# #Goddess#
Gilt bronze head of Sulis Minerva, discovered at Bath in 1727: perhaps ca. Late 1st Century AD.
https://t.cn/A6aEWddZ
特里普拉荪大力寺
特里普拉荪大力寺 距离阿加尔塔拉约55公里。公元1501年,土邦主 Dhanya Manikya Dev建造了神庙Tripura Sundari Temple,是51个Shakti Peeths圣地(夏克提女神(Shakti)身体部位掉落的地方)之一。这里蕴含着强烈的宗教意义,因为据信在湿婆的宇宙之舞时,娑提女神(Goddess Sati)的右脚掉落在这里。
神庙由典型的孟加拉小屋式建筑的方形圣殿组成,冠有圆锥形庙顶。它神采奕奕地矗立在一座小山丘上,庙内有两座相同的神像,时母的神像以Soroshi化身的形式在神庙中被敬拜。每年神庙附近会举行著名的排灯节聚会,吸引了二十多万朝圣者。
Tripura Sundari Temple
The Tripura Sundari Temple is located at a distance of 55 km from Agartala. It was constructed by Maharaja Dhanya Manikya Dev in 1501 AD, and is regarded as one of the 51 shaktipeethas (devotional shrines where the severed body parts of Goddess Sati fell) of Hindu pilgrims in India. The religious significance of this place is quite strong as it is believed that Goddess Sati's right foot fell here during Lord Shiva's dance of cosmic destruction.
The temple consists of a square type sanctum of the typical Bengali-hut style construction with a conical dome. It stands gloriously on a hillock possessing two identical images of the same deity inside the temple. The idol of Goddess Kali is worshipped at the temple of Tripura Sundari in the form of Soroshi. Every year a famous Diwali mela near the temple attracts more than two lakh pilgrims.
特里普拉荪大力寺 距离阿加尔塔拉约55公里。公元1501年,土邦主 Dhanya Manikya Dev建造了神庙Tripura Sundari Temple,是51个Shakti Peeths圣地(夏克提女神(Shakti)身体部位掉落的地方)之一。这里蕴含着强烈的宗教意义,因为据信在湿婆的宇宙之舞时,娑提女神(Goddess Sati)的右脚掉落在这里。
神庙由典型的孟加拉小屋式建筑的方形圣殿组成,冠有圆锥形庙顶。它神采奕奕地矗立在一座小山丘上,庙内有两座相同的神像,时母的神像以Soroshi化身的形式在神庙中被敬拜。每年神庙附近会举行著名的排灯节聚会,吸引了二十多万朝圣者。
Tripura Sundari Temple
The Tripura Sundari Temple is located at a distance of 55 km from Agartala. It was constructed by Maharaja Dhanya Manikya Dev in 1501 AD, and is regarded as one of the 51 shaktipeethas (devotional shrines where the severed body parts of Goddess Sati fell) of Hindu pilgrims in India. The religious significance of this place is quite strong as it is believed that Goddess Sati's right foot fell here during Lord Shiva's dance of cosmic destruction.
The temple consists of a square type sanctum of the typical Bengali-hut style construction with a conical dome. It stands gloriously on a hillock possessing two identical images of the same deity inside the temple. The idol of Goddess Kali is worshipped at the temple of Tripura Sundari in the form of Soroshi. Every year a famous Diwali mela near the temple attracts more than two lakh pilgrims.
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