A 21-year-old man with refractory acute myeloid leukemia presented with itching and tearing in both eyes 1 month after receiving a hematopoietic stem-cell transplant from an HLA-mismatched, unrelated donor. Three weeks after transplantation, he received a diagnosis of grade 4 acute graft-versus-host disease (GVHD) involving the skin, gut, and liver. An examination revealed that his visual acuity was not affected. The corneas in both eyes appeared normal, but pseudomembranes of the upper and lower tarsal conjunctivae could be seen (Panel A). The pseudomembrane of one eye was removed (Panel B), and histopathological analysis revealed fibrinous exudates, macrophages, and solitary granulocytes; no microorganisms were detected. A diagnosis of grade 3 acute ocular GVHD was made, and treatment with topical prednisolone was initiated. Acute ocular GVHD with pseudomembranes is a possible complication of hematopoietic stem-cell transplantation and is associated with a poor prognosis. In this patient, to prevent conjunctival scarring, the pseudomembranes were removed regularly until they no longer appeared, after 3 weeks of treatment. Remission of acute GVHD was achieved after treatment with glucocorticoids and with additional immunosuppression. Moderate chronic GVHD involving the skin, mouth, eyes, and fascia developed 1 year later.
#医学生Medic##medicaltalks##内科#
#医学生Medic##medicaltalks##内科#
【过峰!洪峰已通过长江汉口至九江江段!】#长江洪峰已通过武汉# 据长江水利委员会水文局实时水情监视及预报分析:长江中下游洪水洪峰已通过汉口至九江江段。长江干流汉口站,洪峰水位28.77米,洪峰出现时间2020年7月12日23时。本轮洪峰水位居1865年以来第四高,仅次于1954、1998、1999年。Water levels at Hankou hydrologic station in central China, a crucial point of the Yangtze River, dropped Monday, as the flood peak passed through the section, according to the Bureau of Hydrology of the Changjiang (Yangtze) River Water Resources Commission. Statistics provided by the bureau showed that the Hankou station in Hubei Province registered a water level of 28.74 meters at 5:00 p.m. Monday, lower than the peak of 28.77 measured at 11:00 p.m. Sunday. The peak level this time ranked fourth in history since 1865, after the levels in 1954, 1998, and 1999, according to the bureau.
【过峰!洪峰已通过长江汉口至九江江段!】#长江洪峰已通过武汉# 据长江水利委员会水文局实时水情监视及预报分析:长江中下游洪水洪峰已通过汉口至九江江段。长江干流汉口站,洪峰水位28.77米,洪峰出现时间2020年7月12日23时。本轮洪峰水位居1865年以来第四高,仅次于1954、1998、1999年。Water levels at Hankou hydrologic station in central China, a crucial point of the Yangtze River, dropped Monday, as the flood peak passed through the section, according to the Bureau of Hydrology of the Changjiang (Yangtze) River Water Resources Commission. Statistics provided by the bureau showed that the Hankou station in Hubei Province registered a water level of 28.74 meters at 5:00 p.m. Monday, lower than the peak of 28.77 measured at 11:00 p.m. Sunday. The peak level this time ranked fourth in history since 1865, after the levels in 1954, 1998, and 1999, according to the bureau.
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