OPRA Trial

Ph2 trial w/ random to induction CTH followed by CRT （INCT-CRT） or vice versa（CRT-CNCT）
Stage II（T3-4, N0）/III（any T, N1-2） rectal cancer
cCR/nCR were offered WW, iCR were recommended TME

: DFS
: TME-free survival（Organ preservation）

RESULTS
324 pts, median FU 5.1 y
3-y DFS rates: INCT-CRT 76%，CRT-CNCT 76% （no sig）
5-y DFS rates: INCT-CRT 71%，CRT-CNCT 69%（no sig）
An improvement in DFS among patients treated with TNT and selective WW compared with historical controls was not met
cN1+ on baseline MRI was the only variable associated with DFS
TME-free survival: INCT-CRT 39%, CRT-CNCT 54% (P = 0.012)
5-y OS rates: INCT-CRT 88%，CRT-CNCT 85%（no sig）
5-y LRFS rates: INCT-CRT 94%，CRT-CNCT 90%（no sig）
5-y DMFS rates: INCT-CRT 80%，CRT-CNCT 78%（no sig）
94% of regrowth within 2 y, 99% within 3 y，patients with rectal cancer offered WW after neoadjuvant therapy should have very close surveillance during the first 3 years.
5-y organ preservation rates: INCT-CRT 39%，CRT-CNCT 54%（P = .012）
DFS similar for TME post-restaging and WW followed by TME post-regrowth (both 64%, no sig)
Distant metastasis similar for TME post-restaging and WW followed by TME post-regrowth
~10% had a pCR
3-y OP rates：cCR 77%，nCR 40% (P < .001).
3-y DFS rates：cCR 88%，nCR 69% ，iCR：56% (P < .001)
Clinical tumor response grade was associated with DFS, LRFS, DMFS, and OS.

目前感觉TNT模式的优势就是保留器官，提高生活质量。

#张真源周边中转站[超话]#
“今日我若冷眼旁观，他日祸临己身，则无人为我摇旗呐喊”人性啊
[泪]被跑三年了，真的没有姐妹共鸣了吗，[泪][泪]呜呜呜呜，进500名受害姐妹，金额怎么着也有几千了，更有甚者17岁的生日礼物现在都20岁了[苦涩]，呜呜呜呜我们怎么这么苦呜呜呜呜[泪][泪](´ー`)y━~~，你们没有心，退款接龙倒是接了没下文了，说发货三年了也没有发，呜呜你知道这三年我们是怎么过的吗呜呜[泪]#张真源[超话]##TNT时代少年团[超话]##时代少年团周边中转站tnt[超话]#

#时代少年团[超话]#马嘉祺首字母是“M”，丁程鑫首字母是“D”，宋亚轩首字母是“S”，刘耀文首字母是“L”，张真源首字母是“Z”，严浩翔首字母是“Y”，贺峻霖首字母是“H”，连起来就是：“My dream seems like zealous youth happiness"翻译过来就是：“我的梦想像青春的狂热幸福”

有一种聪明叫马嘉祺有一种帅气叫丁程鑫有一种可爱叫宋亚轩有一种勇敢叫刘耀文有一种真诚叫张真源有一种冷酷叫严浩翔有一种活泼叫贺峻霖TNT不萌，世界颤抖！TNT不帅，世界颠倒，TNT不酷，世界混乱！TNT,雄起！