Join Us｜ACT China Office Is Now Recruiting!
2024，全球权威教育及职业测评公司、教育服务行业的佼佼者，ACT向您发出工作邀约！加入ACT中国办公室，帮助数百万学生实现国际教育梦想、成就学业与事业的成功！
Job Description
As the Business Development Director, you will play a pivotal role in driving growth and revenue streams in the Chinese market, with a focus on expanding the reach of the ACT products available in the International markets. You will leverage your expertise in understanding customer needs and harnessing the diverse education and assessment assets available globally to create innovative products. Reporting directly to the Regional Director (China) and collaborating with cross-functional teams, you will be instrumental in ACT's mission to enhance educational experiences.
Responsibilities
The duties include (and are not limited to):
New Program Development and Deployment
1. Design and develop cutting-edge learning and assessment programs utilizing ACT's international education and assessment assets.
2. Craft a comprehensive growth strategy for new programs and business models while strengthening ACT's brand presence.
Program Sales and License Agreement
1. Identify and cultivate new business opportunities, from prospecting and lead generation to contract negotiations and license agreement drafting and closure.
2. Provide exceptional post-sale support and maintain long-term client relationships.
Channel Development and Management
1. Establish, appoint, coordinate and support Independent Service Providers (ISPs), vendors and other Channel Partners to expand the client base.
2. Conduct regular review with ISPs and Channel Partners to ensure alignment with business objectives.
Other Business Activities
1. Cultivate and maintain strategic external relationships within the education industry, fostering partnerships and collaborations.
2. Represent ACT at industry events and conferences, acting as a catalyst for expanding our business network.
Requirements
Qualifications and Experience:
1. At least Bachelor’s degree in a related field related (e.g., business management, marketing commerce, education) from an accredited university.
2. Overseas study experience in the United States, Europe, Canada, Australia, New Zealand or Singapore is advantageous.
3. Minimum of 3 consecutive years of proven working experience as a business development manager, sales executive, or in a relevant role.
4. Demonstrated track record of consistently achieving or exceeding sales targets.
5. Extensive existing connections within institutes and organizations in the education industry.
Skills and Abilities:
1. In-depth knowledge of the national and international education systems and student markets.
2. Excellent interpersonal, presentation, and communication skills, including fluency in English.
3. Strong time management, project management, and planning abilities.
4. Exceptional business acumen and the ability to recognize and capitalize on emerging opportunities, trends, and perspectives.
5. Proficiency in technical tools, including Microsoft Office, Salesforce, and data analytics software. A willingness and aptitude to learn new software is essential.
How to Apply
Submit your CV to: shanghaioffice@act.org
Join ACT, act now!
我们期待您的加入！
2024，全球权威教育及职业测评公司、教育服务行业的佼佼者，ACT向您发出工作邀约！加入ACT中国办公室，帮助数百万学生实现国际教育梦想、成就学业与事业的成功！
Job Description
As the Business Development Director, you will play a pivotal role in driving growth and revenue streams in the Chinese market, with a focus on expanding the reach of the ACT products available in the International markets. You will leverage your expertise in understanding customer needs and harnessing the diverse education and assessment assets available globally to create innovative products. Reporting directly to the Regional Director (China) and collaborating with cross-functional teams, you will be instrumental in ACT's mission to enhance educational experiences.
Responsibilities
The duties include (and are not limited to):
New Program Development and Deployment
1. Design and develop cutting-edge learning and assessment programs utilizing ACT's international education and assessment assets.
2. Craft a comprehensive growth strategy for new programs and business models while strengthening ACT's brand presence.
Program Sales and License Agreement
1. Identify and cultivate new business opportunities, from prospecting and lead generation to contract negotiations and license agreement drafting and closure.
2. Provide exceptional post-sale support and maintain long-term client relationships.
Channel Development and Management
1. Establish, appoint, coordinate and support Independent Service Providers (ISPs), vendors and other Channel Partners to expand the client base.
2. Conduct regular review with ISPs and Channel Partners to ensure alignment with business objectives.
Other Business Activities
1. Cultivate and maintain strategic external relationships within the education industry, fostering partnerships and collaborations.
2. Represent ACT at industry events and conferences, acting as a catalyst for expanding our business network.
Requirements
Qualifications and Experience:
1. At least Bachelor’s degree in a related field related (e.g., business management, marketing commerce, education) from an accredited university.
2. Overseas study experience in the United States, Europe, Canada, Australia, New Zealand or Singapore is advantageous.
3. Minimum of 3 consecutive years of proven working experience as a business development manager, sales executive, or in a relevant role.
4. Demonstrated track record of consistently achieving or exceeding sales targets.
5. Extensive existing connections within institutes and organizations in the education industry.
Skills and Abilities:
1. In-depth knowledge of the national and international education systems and student markets.
2. Excellent interpersonal, presentation, and communication skills, including fluency in English.
3. Strong time management, project management, and planning abilities.
4. Exceptional business acumen and the ability to recognize and capitalize on emerging opportunities, trends, and perspectives.
5. Proficiency in technical tools, including Microsoft Office, Salesforce, and data analytics software. A willingness and aptitude to learn new software is essential.
How to Apply
Submit your CV to: shanghaioffice@act.org
Join ACT, act now!
我们期待您的加入！
大家好！我是湖北的脑控受害者余凤莲，脑控狗总是用脑控武器，控制家里出现大量苍蝇、蚊子，象虫、甚至蛆虫、老鼠等
家里的蚊蝇纸、灭蚊器、灭蚊水、灭蚊片等啥都不管用，满屋子全是苍蝇蚊子象虫蛆虫老鼠等。
脑控狗真是变态到极点，竟然用脑控武器控出蛆虫，爬在我手臂、腿子上
有时吃饭的时候，碗上面突然爬出个白蛆虫。
以下是英语翻译:
The following is an English translation:
Hello everyone! I am Yu Fenglian, a brain control victim from Hubei. Brain control dogs always use brain control weapons to control a large number of flies, mosquitoes, elephants, and even maggots, mice, etc. in their homes
The mosquito paper, mosquito repellent, mosquito repellent water, mosquito repellent tablets, etc. at home are useless, and the room is filled with flies, mosquitoes, insects, maggots, mice, and so on.
The brain controlled dog is really abnormal, using a brain controlled weapon to control maggots and crawl on my arms and legs
Sometimes while eating, a white maggot suddenly crawls out of the bowl.#苏亚雷斯[超话]#
家里的蚊蝇纸、灭蚊器、灭蚊水、灭蚊片等啥都不管用，满屋子全是苍蝇蚊子象虫蛆虫老鼠等。
脑控狗真是变态到极点，竟然用脑控武器控出蛆虫，爬在我手臂、腿子上
有时吃饭的时候，碗上面突然爬出个白蛆虫。
以下是英语翻译:
The following is an English translation:
Hello everyone! I am Yu Fenglian, a brain control victim from Hubei. Brain control dogs always use brain control weapons to control a large number of flies, mosquitoes, elephants, and even maggots, mice, etc. in their homes
The mosquito paper, mosquito repellent, mosquito repellent water, mosquito repellent tablets, etc. at home are useless, and the room is filled with flies, mosquitoes, insects, maggots, mice, and so on.
The brain controlled dog is really abnormal, using a brain controlled weapon to control maggots and crawl on my arms and legs
Sometimes while eating, a white maggot suddenly crawls out of the bowl.#苏亚雷斯[超话]#
CD4/CD8比值：非艾滋相关疾病的指标
来源：中国疾控艾防中心
CD4+T淋巴细胞是HIV感染最主要的靶细胞，HIV感染人体后会引起CD4+T淋巴细胞进行性减少。近年来，抗逆转录病毒治疗(ART)取得了良好效果，在大多数接受治疗的HIV感染者中可达到病毒完全抑制，CD4细胞也可逐渐恢复至接近正常人水平（＞500个／μＬ）。但HIV感染者仍有可能因为存在异常的免疫活化引起恶性肿瘤、终末期肾病、肝功能衰竭、胰腺炎、心血管疾病和糖尿病等非艾滋相关疾病（Non-AIDS-defining illnesses）[1]。因此，仅依靠CD4+T淋巴细胞计数，并不能完全反映HIV感染者免疫功能的恢复状况。研究发现CD4+T淋巴细胞与CD8+T淋巴细胞的比值，简称为CD4/CD8比值，可作为非艾滋相关疾病的生物学标志物[2]。
临床上通常定义CD4/CD8比值≥1.0为正常，<1.0为比值倒置。研究表明CD4/CD8比值倒置的患者患非艾滋相关疾病的风险更高[3]，特别是CD4/CD8比值<0.3的患者更有可能发生严重的非艾滋病相关疾病[4]。在进行抗病毒治疗的HIV感染者中，CD4/CD8比值需要一定时间逐渐恢复正常，在一项4206名HIV感染者的观察队列中，仅有7.2%感染者经过平均2.77年ART后CD4/CD8比值达到正常[5]。在另一项3236名HIV感染者的队列中，ART一年后达到CD4/CD8比值正常的感染者占比4.4%，两年后达到CD4/CD8比值正常的感染者占比11.5%，五年后达到CD4/CD8比值正常的感染者占比29.4%[4]。
研究表明HIV感染者在感染后启动ART的时间、DNA储存库、ART方案和机体免疫状态等可能影响CD4/CD8比值[3,5-10]。有助于提高CD4/CD8比值的建议包括：
①尽早开始抗病毒治疗。早期启动并持续坚持ART的HIV感染者具有更高的机会可达到正常的CD4/CD8比值，早期ART有助于降低CD4+T淋巴细胞及CD8+T淋巴细胞的活化水平，也有助于降低HIV储存库大小，可较快重建免疫系统。
②优化抗病毒治疗方案。非核苷类或整合酶方案更易促进CD4/CD8比值恢复正常，感染者应该在医生的指导下选择优化的抗病毒治疗方案。
③控制炎症减少免疫激活。身体长期处于慢性炎症状态会延缓CD4/CD8比值的恢复。感染者应该选择健康的生活方式，如清淡饮食、规律作息等，在医生的指导下通过合理的手段控制炎症，促进免疫功能恢复。
（刘佩 中国疾控艾防中心）
参考文献：
[1] Mocroft A, Reiss P, Gasiorowski J, et al. Serious fatal and nonfatal non-AIDS-defining illnesses in Europe. J Acquir Immune Defic Syndr. 2010 Oct;55(2):262-70.
[2] Serrano-Villar S, Deeks SG. CD4/CD8 ratio: an emerging biomarker for HIV. Lancet HIV. 2015 Mar;2(3):e76-7.
[3] Saracino A, Bruno G, Scudeller L, et al. Chronic inflammation in a long-term cohort of HIV-infected patients according to the normalization of the CD4:CD8 ratio. AIDS Res Hum Retroviruses. 2014 Dec;30(12):1178-84.
[4] Mussini C, Lorenzini P, Cozzi-Lepri A, et al. CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study. Lancet HIV. 2015 Mar;2(3):e98-106.
[5] Leung V, Gillis J, Raboud J, et al. Predictors of CD4:CD8 ratio normalization and its effect on health outcomes in the era of combination antiretroviral therapy. PLoS One. 2013 Oct 30;8(10):e77665.
[6] Chun TW, Justement JS, Pandya P, et al. Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy. J Infect Dis. 2002 Jun 1;185(11):1672-6.
[7] Serrano-Villar S, Zhou Y, Rodgers AJ, et al. Different impact of raltegravir versus efavirenz on CD4/CD8 ratio recovery in HIV-infected patients. J Antimicrob Chemother. 2017;72(1):235-239.
[8] De Salvador-Guillouët F, Sakarovitch C, Durant J, et al. Antiretroviral Regimens and CD4/CD8 Ratio Normalization in HIV-Infected Patients during the Initial Year of Treatment: A Cohort Study. PLoS One. 2015;10(10):e0140519.
[9] Masiá M, Padilla S, Barber X, et al. Comparative Impact of Suppressive Antiretroviral Regimens on the CD4/CD8 T-Cell Ratio: A Cohort Study. Medicine (Baltimore). 2016;95(11):e3108.
[10] Caby F, Guihot A, Lambert-Niclot S, et al. Determinants of a Low CD4/CD8 Ratio in HIV-1-Infected Individuals Despite Long-term Viral Suppression. Clin Infect Dis. 2016;62(10):1297-1303.
来源：中国疾控艾防中心
CD4+T淋巴细胞是HIV感染最主要的靶细胞，HIV感染人体后会引起CD4+T淋巴细胞进行性减少。近年来，抗逆转录病毒治疗(ART)取得了良好效果，在大多数接受治疗的HIV感染者中可达到病毒完全抑制，CD4细胞也可逐渐恢复至接近正常人水平（＞500个／μＬ）。但HIV感染者仍有可能因为存在异常的免疫活化引起恶性肿瘤、终末期肾病、肝功能衰竭、胰腺炎、心血管疾病和糖尿病等非艾滋相关疾病（Non-AIDS-defining illnesses）[1]。因此，仅依靠CD4+T淋巴细胞计数，并不能完全反映HIV感染者免疫功能的恢复状况。研究发现CD4+T淋巴细胞与CD8+T淋巴细胞的比值，简称为CD4/CD8比值，可作为非艾滋相关疾病的生物学标志物[2]。
临床上通常定义CD4/CD8比值≥1.0为正常，<1.0为比值倒置。研究表明CD4/CD8比值倒置的患者患非艾滋相关疾病的风险更高[3]，特别是CD4/CD8比值<0.3的患者更有可能发生严重的非艾滋病相关疾病[4]。在进行抗病毒治疗的HIV感染者中，CD4/CD8比值需要一定时间逐渐恢复正常，在一项4206名HIV感染者的观察队列中，仅有7.2%感染者经过平均2.77年ART后CD4/CD8比值达到正常[5]。在另一项3236名HIV感染者的队列中，ART一年后达到CD4/CD8比值正常的感染者占比4.4%，两年后达到CD4/CD8比值正常的感染者占比11.5%，五年后达到CD4/CD8比值正常的感染者占比29.4%[4]。
研究表明HIV感染者在感染后启动ART的时间、DNA储存库、ART方案和机体免疫状态等可能影响CD4/CD8比值[3,5-10]。有助于提高CD4/CD8比值的建议包括：
①尽早开始抗病毒治疗。早期启动并持续坚持ART的HIV感染者具有更高的机会可达到正常的CD4/CD8比值，早期ART有助于降低CD4+T淋巴细胞及CD8+T淋巴细胞的活化水平，也有助于降低HIV储存库大小，可较快重建免疫系统。
②优化抗病毒治疗方案。非核苷类或整合酶方案更易促进CD4/CD8比值恢复正常，感染者应该在医生的指导下选择优化的抗病毒治疗方案。
③控制炎症减少免疫激活。身体长期处于慢性炎症状态会延缓CD4/CD8比值的恢复。感染者应该选择健康的生活方式，如清淡饮食、规律作息等，在医生的指导下通过合理的手段控制炎症，促进免疫功能恢复。
（刘佩 中国疾控艾防中心）
参考文献：
[1] Mocroft A, Reiss P, Gasiorowski J, et al. Serious fatal and nonfatal non-AIDS-defining illnesses in Europe. J Acquir Immune Defic Syndr. 2010 Oct;55(2):262-70.
[2] Serrano-Villar S, Deeks SG. CD4/CD8 ratio: an emerging biomarker for HIV. Lancet HIV. 2015 Mar;2(3):e76-7.
[3] Saracino A, Bruno G, Scudeller L, et al. Chronic inflammation in a long-term cohort of HIV-infected patients according to the normalization of the CD4:CD8 ratio. AIDS Res Hum Retroviruses. 2014 Dec;30(12):1178-84.
[4] Mussini C, Lorenzini P, Cozzi-Lepri A, et al. CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study. Lancet HIV. 2015 Mar;2(3):e98-106.
[5] Leung V, Gillis J, Raboud J, et al. Predictors of CD4:CD8 ratio normalization and its effect on health outcomes in the era of combination antiretroviral therapy. PLoS One. 2013 Oct 30;8(10):e77665.
[6] Chun TW, Justement JS, Pandya P, et al. Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy. J Infect Dis. 2002 Jun 1;185(11):1672-6.
[7] Serrano-Villar S, Zhou Y, Rodgers AJ, et al. Different impact of raltegravir versus efavirenz on CD4/CD8 ratio recovery in HIV-infected patients. J Antimicrob Chemother. 2017;72(1):235-239.
[8] De Salvador-Guillouët F, Sakarovitch C, Durant J, et al. Antiretroviral Regimens and CD4/CD8 Ratio Normalization in HIV-Infected Patients during the Initial Year of Treatment: A Cohort Study. PLoS One. 2015;10(10):e0140519.
[9] Masiá M, Padilla S, Barber X, et al. Comparative Impact of Suppressive Antiretroviral Regimens on the CD4/CD8 T-Cell Ratio: A Cohort Study. Medicine (Baltimore). 2016;95(11):e3108.
[10] Caby F, Guihot A, Lambert-Niclot S, et al. Determinants of a Low CD4/CD8 Ratio in HIV-1-Infected Individuals Despite Long-term Viral Suppression. Clin Infect Dis. 2016;62(10):1297-1303.
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