昨日中午一顿·煮海 ～ 结束这趟潮汕之旅！是个完美ending ！[比耶][比耶]
前几日忍住了 ～ 没去吃甜品！路过好几家店 ～ 目测品质均不佳！煮海这一碗杏汁豆花 ～ 真的没有辜负我多日滴等待！杏仁浓郁、豆花滑嫩 ～ 啧啧啧！[送花花][送花花]
听闻隔壁桌女生不爱吃 ～ 我都恨不得抢过来炫完它！[幹飯人][幹飯人]（#打工人终于结束了春假−需要好好干活啰#）
前几日忍住了 ～ 没去吃甜品！路过好几家店 ～ 目测品质均不佳！煮海这一碗杏汁豆花 ～ 真的没有辜负我多日滴等待！杏仁浓郁、豆花滑嫩 ～ 啧啧啧！[送花花][送花花]
听闻隔壁桌女生不爱吃 ～ 我都恨不得抢过来炫完它！[幹飯人][幹飯人]（#打工人终于结束了春假−需要好好干活啰#）
#看馆# 深圳博物馆之香林宝像−犍陀罗艺术展
上午我到深圳博物馆参观，直奔犍陀罗艺术展。该展览由深圳博物馆与巴基斯坦国家遗产与文化署考古与博物馆局、故宫博物院联合主办，共展出文物203件（套），包括巴基斯坦7家博物馆的173件（套）文物和故宫博物院所藏30件（套）文物，巴方文物以考古发掘为主，包括佛教造像、佛塔建筑构件等犍陀罗石雕艺术以及各类金银器，充分展示犍陀罗艺术风格的多样性。本展览旨在以古代犍陀罗文明发展的视角，展现犍陀罗文化的艺术魅力及其对中国乃至东亚的深刻影响。
古代犍陀罗的考古遗址，主要分布于今天的兴都库什山和喀喇昆仑山的南端，具体包括巴基斯坦北部的白沙瓦河谷到印度河东岸，以及阿富汗喀布尔河谷东部一带，这里是丝绸之路连接南亚次大陆的重要枢纽，地中海文明、伊朗文明中亚草原文明和印度文明的交汇之地。
在长达千年的历史长河中，犍陀罗一直为不同的王朝政权所掌控，文化面貌丰富多样，地区间文化类型互相混杂。不同语言、不同族群和不同文化背景的统治者先后掌控犍陀罗地区，奠定其历史文化发展与繁荣的基础。 https://t.cn/A6qE9qJm
上午我到深圳博物馆参观，直奔犍陀罗艺术展。该展览由深圳博物馆与巴基斯坦国家遗产与文化署考古与博物馆局、故宫博物院联合主办，共展出文物203件（套），包括巴基斯坦7家博物馆的173件（套）文物和故宫博物院所藏30件（套）文物，巴方文物以考古发掘为主，包括佛教造像、佛塔建筑构件等犍陀罗石雕艺术以及各类金银器，充分展示犍陀罗艺术风格的多样性。本展览旨在以古代犍陀罗文明发展的视角，展现犍陀罗文化的艺术魅力及其对中国乃至东亚的深刻影响。
古代犍陀罗的考古遗址，主要分布于今天的兴都库什山和喀喇昆仑山的南端，具体包括巴基斯坦北部的白沙瓦河谷到印度河东岸，以及阿富汗喀布尔河谷东部一带，这里是丝绸之路连接南亚次大陆的重要枢纽，地中海文明、伊朗文明中亚草原文明和印度文明的交汇之地。
在长达千年的历史长河中，犍陀罗一直为不同的王朝政权所掌控，文化面貌丰富多样，地区间文化类型互相混杂。不同语言、不同族群和不同文化背景的统治者先后掌控犍陀罗地区，奠定其历史文化发展与繁荣的基础。 https://t.cn/A6qE9qJm
---memo---
Fig. 1: AQP4-competent haematopoietic cells contribute to the negative selection of AQP4-specific T cells.
a, Criss-cross bone marrow (BM) chimeras of WT and Aqp4−/− mice were immunized with the I-Ab-restricted epitope of AQP4 (P41) and tested for the frequency of AQP4-specific T cells with an AQP4(205–215)–I-Ab tetramer (P41-10–I-Ab) compared to a control I-Ab tetramer (PLP(9–20)–I-Ab; control I-Ab). Representative cytograms and quantification of absolute P41-10–I-Ab+ T cell counts determined in the spleen and draining lymph nodes (secondary lymphoid tissue (sec LyTi)). Data are mean ± s.d. Statistical analysis was performed using two-tailed t-tests, with WT into WT chimeras used as the reference; *P < 0.05. The symbols indicate biological replicates. Zero values are not depicted in the bar graph due to logarithmic scaling. b, The fraction of thymic B cells. The mean ± s.d. thymic B cell fraction (%) is shown at the top right. n = 7 biological replicates. c, Aqp4 expression in fluorescence-activated cell sorting (FACS)-sorted TECs (live CD45−EPCAM+), thymic B cells (live CD45+EPCAM−CD19+) and thymic dendritic cells (live CD45+EPCAM−CD19−CD11c+MHC-IIhigh) normalized to Aqp4 expression in astrocytes. Data are mean ± s.d. relative gene expression (RQ). The symbols indicate biological replicates; zero values are not depicted in the graph due to logarithmic scaling. n.d., not detected in three biological replicates. d, Representative CD19 immunostaining in WT thymus. n = 2 independent experiments. Scale bars, 500 µm (left) and 50 µm (right). e, Triple immunofluorescence staining of CD19, AQP4 and EPCAM in mouse thymus from WT, Aqp4−/− and Aqp4ΔB mice. n = 2 independent experiments. Individual channels aligned below a larger merged microphotograph. Scale bars, 5 μm (bottom) and 20 μm (top). f, B cell staining (CD20) in newborn human thymus. Scale bar, 200 μm. g–i, Double immunofluorescence staining for CD20 and AQP4 in the human thymus. Scale bars, 50 μm (g), 5 µm (h) and 1 µm (i). g, Overview. h, Magnification of the area marked by the rectangle in g. i, z-axis cross-section along the dashed line indicated in h (top). Bottom, the corresponding signal intensity profile of the immunofluorescence for CD20, AQP4 and DAPI in relation to the distance from the cell centre in µm is shown. n = 2 independent experiments.
Fig. 1: AQP4-competent haematopoietic cells contribute to the negative selection of AQP4-specific T cells.
a, Criss-cross bone marrow (BM) chimeras of WT and Aqp4−/− mice were immunized with the I-Ab-restricted epitope of AQP4 (P41) and tested for the frequency of AQP4-specific T cells with an AQP4(205–215)–I-Ab tetramer (P41-10–I-Ab) compared to a control I-Ab tetramer (PLP(9–20)–I-Ab; control I-Ab). Representative cytograms and quantification of absolute P41-10–I-Ab+ T cell counts determined in the spleen and draining lymph nodes (secondary lymphoid tissue (sec LyTi)). Data are mean ± s.d. Statistical analysis was performed using two-tailed t-tests, with WT into WT chimeras used as the reference; *P < 0.05. The symbols indicate biological replicates. Zero values are not depicted in the bar graph due to logarithmic scaling. b, The fraction of thymic B cells. The mean ± s.d. thymic B cell fraction (%) is shown at the top right. n = 7 biological replicates. c, Aqp4 expression in fluorescence-activated cell sorting (FACS)-sorted TECs (live CD45−EPCAM+), thymic B cells (live CD45+EPCAM−CD19+) and thymic dendritic cells (live CD45+EPCAM−CD19−CD11c+MHC-IIhigh) normalized to Aqp4 expression in astrocytes. Data are mean ± s.d. relative gene expression (RQ). The symbols indicate biological replicates; zero values are not depicted in the graph due to logarithmic scaling. n.d., not detected in three biological replicates. d, Representative CD19 immunostaining in WT thymus. n = 2 independent experiments. Scale bars, 500 µm (left) and 50 µm (right). e, Triple immunofluorescence staining of CD19, AQP4 and EPCAM in mouse thymus from WT, Aqp4−/− and Aqp4ΔB mice. n = 2 independent experiments. Individual channels aligned below a larger merged microphotograph. Scale bars, 5 μm (bottom) and 20 μm (top). f, B cell staining (CD20) in newborn human thymus. Scale bar, 200 μm. g–i, Double immunofluorescence staining for CD20 and AQP4 in the human thymus. Scale bars, 50 μm (g), 5 µm (h) and 1 µm (i). g, Overview. h, Magnification of the area marked by the rectangle in g. i, z-axis cross-section along the dashed line indicated in h (top). Bottom, the corresponding signal intensity profile of the immunofluorescence for CD20, AQP4 and DAPI in relation to the distance from the cell centre in µm is shown. n = 2 independent experiments.
✋热门推荐