Update on the status of Dr . Tanveer Ahmed
Agha Hunain Abbas Khan
"My dear Pakistanis, I am writing this to update you on the status of Dr. Tanveer Ahmed. As you know, Dr. Tanveer has been suffering from Guillain Barre Syndrome, causing multiple organ failure. He has been hospitalized for many weeks now. Most recent update from Kunming First City Hospital has stated that Dr. Ahmed can now, on occasion, come off the ventilator and exercise his breathing. Which is tremendously good news. Additionally, the threat of organ failure is no longer acute, with normal kidney and liver functioning. However, unfortunately, Dr. Tanveer still faces a long road to recovery.
I would also like to take this opportunity to thank the Pakistanis who very generously stepped forward to help Dr. Ahmed, in this time of need. The response was overwhelming, over 200 people donated, raising thousands. That money has now been forwarded to the hospital account, for Dr. Ahmed's continuing treatment.
Moving forward, if anyone wishes to help, the donation app: shuidichou (水滴筹) may kindly be used, which is directly linked with Kunming First City Hospital, and the funds will be used for Dr. Tanveer's treatment. The link for the app is attached.
I thank you, as we continue to pray for Tanveer's speedy and full recovery."
Donation link: (please copy the below link and click: SEARCH)
https://t.cn/A6H20YKJ
Agha Hunain Abbas Khan
"My dear Pakistanis, I am writing this to update you on the status of Dr. Tanveer Ahmed. As you know, Dr. Tanveer has been suffering from Guillain Barre Syndrome, causing multiple organ failure. He has been hospitalized for many weeks now. Most recent update from Kunming First City Hospital has stated that Dr. Ahmed can now, on occasion, come off the ventilator and exercise his breathing. Which is tremendously good news. Additionally, the threat of organ failure is no longer acute, with normal kidney and liver functioning. However, unfortunately, Dr. Tanveer still faces a long road to recovery.
I would also like to take this opportunity to thank the Pakistanis who very generously stepped forward to help Dr. Ahmed, in this time of need. The response was overwhelming, over 200 people donated, raising thousands. That money has now been forwarded to the hospital account, for Dr. Ahmed's continuing treatment.
Moving forward, if anyone wishes to help, the donation app: shuidichou (水滴筹) may kindly be used, which is directly linked with Kunming First City Hospital, and the funds will be used for Dr. Tanveer's treatment. The link for the app is attached.
I thank you, as we continue to pray for Tanveer's speedy and full recovery."
Donation link: (please copy the below link and click: SEARCH)
https://t.cn/A6H20YKJ
【流感疫苗都有什么类型？】
全球已上市的流感疫苗分为流感病毒灭活疫苗、流感病毒减毒活疫苗和流感病毒重组疫苗，按照疫苗所含组份，分为三价和四价流感疫苗。
今年三价流感疫苗组份含有A（H3N2）亚型、A（H1N1）pdm09亚型和B（Victoria）系四价流感疫苗组除三价流感疫苗的三个组份外，增加了B（Yamagata）系。与上一年度相比，本年度WHO推荐的疫苗组份中更换了A（HINI）pdm09流感病毒亚型疫苗株。从流感监测数据看，2020年4月至今全球范围内没有再分离出乙型流感病毒B（Yamagata）谱系毒株。
2023—2024流行季我国使用的流感疫苗包括三价灭活流感疫苗(IIV3)、四价灭活流感疫苗（IIV4）和三价减毒活疫苗（LAIV3），其中IIV3有裂解疫苗和亚单位疫苗，可用于≥6月龄人群接种；LAIV3为冻干制剂，可用于3-17岁人群接种；IIV4为裂解疫苗和亚单位疫苗，可用于≥6月龄人群接种。（来源：北京市疾病预防控制中心）
全球已上市的流感疫苗分为流感病毒灭活疫苗、流感病毒减毒活疫苗和流感病毒重组疫苗，按照疫苗所含组份，分为三价和四价流感疫苗。
今年三价流感疫苗组份含有A（H3N2）亚型、A（H1N1）pdm09亚型和B（Victoria）系四价流感疫苗组除三价流感疫苗的三个组份外，增加了B（Yamagata）系。与上一年度相比，本年度WHO推荐的疫苗组份中更换了A（HINI）pdm09流感病毒亚型疫苗株。从流感监测数据看，2020年4月至今全球范围内没有再分离出乙型流感病毒B（Yamagata）谱系毒株。
2023—2024流行季我国使用的流感疫苗包括三价灭活流感疫苗(IIV3)、四价灭活流感疫苗（IIV4）和三价减毒活疫苗（LAIV3），其中IIV3有裂解疫苗和亚单位疫苗，可用于≥6月龄人群接种；LAIV3为冻干制剂，可用于3-17岁人群接种；IIV4为裂解疫苗和亚单位疫苗，可用于≥6月龄人群接种。（来源：北京市疾病预防控制中心）
【Redox Biol：发生支架内再狭窄的2型糖尿病患者高度依赖线粒体脂肪酸氧化】支架内再狭窄(ISR)被定义为冠状动脉支架置入部位的管腔再狭窄，是目前经皮冠状动脉介入治疗(PCI)的主要局限性。2型糖尿病(T2DM)作为PCI术后不良结局的一个重要指标，越来越多地与ISR加速相关。流行病学证明，2型糖尿病患者的ISR风险显著增加。血小板功能障碍是T2DM的典型标志，它通过诱导血管炎症、平滑肌细胞异常迁移以及随之而来的内膜增生，特别是通过血小板分泌颗粒释放生物活性物质，在ISR的发病机制中起着重要作用。
循环血小板暴露于内皮下基质是支架诱导的动脉损伤后立即发生的再狭窄病变形成的早期事件，必然引发血小板的过度活化。静止血小板向激活状态的转变需要大量的化学能，其中大部分来自线粒体氧化磷酸化(OXPHOS)。生理上，葡萄糖是血小板为线粒体OXPHOS供能的代谢底物。而在糖尿病条件下，葡萄糖的可用性是有限的，可能会相应地改变对脂肪酸(FAs)和谷氨酰胺等替代燃料的利用，以维持线粒体ATP的产生。
线粒体燃料依赖性的这些变化对血小板代谢功能至关重要，因为它们可能进一步影响呼吸活动和电子传递链(ETC)的氧化还原状，导致血小板生物能量学的致病性重连。然而，尽管对血小板的代谢可塑性有部分了解，但对于线粒体对某些底物的燃料偏好是否与血小板的特定功能反应有关，更重要的是，与T2DM患者的ISR进展有关，人们知之甚少。同样，尽管线粒体功能障碍已被认为是再狭窄过程的重要因素，但线粒体生物能量学(包括总体呼吸能力以及由特定ETC复合物驱动的呼吸)在ISR发展中的确切作用在很大程度上仍然未知。
近日，来自郑州大学第一附属医院的研究者们在Redox Biol 杂志上发表了题为“Platelet bioenergetic profiling uncovers a metabolic pattern of high dependency on mitochondrial fatty acid oxidation in type 2 diabetic patients who developed in-stent restenosis”的文章，该研究表明在发生ISR的2型糖尿病患者中，血小板的最大呼吸能力和储备呼吸能力都严重受损，高度依赖脂肪酸氧化。https://t.cn/A6H24Zf4
循环血小板暴露于内皮下基质是支架诱导的动脉损伤后立即发生的再狭窄病变形成的早期事件，必然引发血小板的过度活化。静止血小板向激活状态的转变需要大量的化学能，其中大部分来自线粒体氧化磷酸化(OXPHOS)。生理上，葡萄糖是血小板为线粒体OXPHOS供能的代谢底物。而在糖尿病条件下，葡萄糖的可用性是有限的，可能会相应地改变对脂肪酸(FAs)和谷氨酰胺等替代燃料的利用，以维持线粒体ATP的产生。
线粒体燃料依赖性的这些变化对血小板代谢功能至关重要，因为它们可能进一步影响呼吸活动和电子传递链(ETC)的氧化还原状，导致血小板生物能量学的致病性重连。然而，尽管对血小板的代谢可塑性有部分了解，但对于线粒体对某些底物的燃料偏好是否与血小板的特定功能反应有关，更重要的是，与T2DM患者的ISR进展有关，人们知之甚少。同样，尽管线粒体功能障碍已被认为是再狭窄过程的重要因素，但线粒体生物能量学(包括总体呼吸能力以及由特定ETC复合物驱动的呼吸)在ISR发展中的确切作用在很大程度上仍然未知。
近日，来自郑州大学第一附属医院的研究者们在Redox Biol 杂志上发表了题为“Platelet bioenergetic profiling uncovers a metabolic pattern of high dependency on mitochondrial fatty acid oxidation in type 2 diabetic patients who developed in-stent restenosis”的文章，该研究表明在发生ISR的2型糖尿病患者中，血小板的最大呼吸能力和储备呼吸能力都严重受损，高度依赖脂肪酸氧化。https://t.cn/A6H24Zf4
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