A 65-year-old woman with a history of measles encephalitis was evaluated for rapidly progressive weakness in the right arm and recurrent falls. MRI of the head showed restricted diffusion and hyperintensity in the left frontal and left parietal lobes.
#医学生Medic[超话]##medicaltalks#
#医学生Medic[超话]##medicaltalks#
This Cell Type May Trigger Alzheimer's
Microglia are amoeba-like cells that scour the brain for injuries and invaders.
They help clear dead or impaired brain cells and literally gobble up invading microbes. Without them, we'd be in trouble.
In a normal brain, a protein called beta-amyloid is cleared away through our lymphatic system by microglia as molecular junk.
But sometimes it builds up. Certain gene mutations are one culprit in this toxic accumulation. Traumatic brain injury is another, and, perhaps, impaired microglial function.
To date, nearly a dozen genes involved in immune and microglial function have been tied to Alzheimer's.
The first was CD33, identified in 2008.
If CD33 is the yin, a gene called TREM2 is the yang.
Discovered a few years after CD33, TREM2 reins in microglial activation, returning them to their role as cellular housekeepers.
#医学生Medic[超话]##medicaltalks#
Microglia are amoeba-like cells that scour the brain for injuries and invaders.
They help clear dead or impaired brain cells and literally gobble up invading microbes. Without them, we'd be in trouble.
In a normal brain, a protein called beta-amyloid is cleared away through our lymphatic system by microglia as molecular junk.
But sometimes it builds up. Certain gene mutations are one culprit in this toxic accumulation. Traumatic brain injury is another, and, perhaps, impaired microglial function.
To date, nearly a dozen genes involved in immune and microglial function have been tied to Alzheimer's.
The first was CD33, identified in 2008.
If CD33 is the yin, a gene called TREM2 is the yang.
Discovered a few years after CD33, TREM2 reins in microglial activation, returning them to their role as cellular housekeepers.
#医学生Medic[超话]##medicaltalks#
Ageusia is a rare condition that is characterized by a complete loss of taste function of the tongue. It requires differentiation from other taste disorders such as hypogeusia (decreased sensitivity to all tastants), hyperguesia (enhanced gustatory sensitivity), dysgeusia (unpleasant perception of a tastant), and phantogeusia (perception of taste that occurs in the absence of a tastant). Although ageusia is not a life-threatening condition, it can cause discomfort. It can lead to loss of appetite, reduction in weight, and in some cases, may require discontinuation of drugs in already compromised patients; this can result in medical problems and can have a severe psychological impact on the patient.
#医学生Medic[超话]##medicaltalks#
#医学生Medic[超话]##medicaltalks#
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