【Cell Report:骨髓增生异常综合征(MDS)细胞通过细胞外囊泡损害抑制正常的造血功能】骨髓增生异常综合征(MDS)是一种克隆性血液系统恶性肿瘤，由具有体细胞突变的异常造血干细胞(HSCs)引起，以分化障碍、外周血细胞减少和易患急性髓系白血病(AML)为特征。与AML细胞不同，MDS克隆的生长速度通常低于正常造血干细胞，这是因为MDS启动细胞在小鼠MDS模型中表现出竞争劣势。
矛盾的是，MDS克隆并没有被根除，并在长时间的潜伏期后逐渐在骨髓(BM)中与正常的HSCs竞争。为了解释这些相互矛盾的发现，有必要考虑BM微环境和HSCs之间的相互作用。
近日，东京大学的研究者们在“Cell Report”杂志上发表了题为“MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis”的文章，该研究揭示了新的MDS EV-MSC轴在无效造血中的作用。https://t.cn/A6XK2vro
矛盾的是，MDS克隆并没有被根除，并在长时间的潜伏期后逐渐在骨髓(BM)中与正常的HSCs竞争。为了解释这些相互矛盾的发现，有必要考虑BM微环境和HSCs之间的相互作用。
近日，东京大学的研究者们在“Cell Report”杂志上发表了题为“MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis”的文章，该研究揭示了新的MDS EV-MSC轴在无效造血中的作用。https://t.cn/A6XK2vro
“Between the past and the future of an event, there exists an ‘intermediate zone’, an ‘expanded present’; a zone that is neither past nor future.
The duration of this intermediate zone depends on where an event takes place relative to you, the greater the distance of the event from you, the longer the duration of the extended present.
At a distance of a few metres from your nose, the duration of what for you is no more than a few nanoseconds: next to nothing
On the other side of the ocean, the duration of this intermediate zone is a thousandth of a second, still well below the threshold of our perception of time
on the Moon the duration of the expanded present is a few seconds,
on Mars it is a quarter of an hour.
neither in our past nor in our future. They are elsewhere. We had never before been aware of this ‘elsewhere’
it makes no sense to say of an event on Mars that it is taking place ‘just now’,
‘absolute simultaneity’ does not exist: there is no collection of events in the universe which exist ‘now’.
those that are ‘neither-past-nor-future’; these do not form a single instant: they have themselves a duration.”
The duration of this intermediate zone depends on where an event takes place relative to you, the greater the distance of the event from you, the longer the duration of the extended present.
At a distance of a few metres from your nose, the duration of what for you is no more than a few nanoseconds: next to nothing
On the other side of the ocean, the duration of this intermediate zone is a thousandth of a second, still well below the threshold of our perception of time
on the Moon the duration of the expanded present is a few seconds,
on Mars it is a quarter of an hour.
neither in our past nor in our future. They are elsewhere. We had never before been aware of this ‘elsewhere’
it makes no sense to say of an event on Mars that it is taking place ‘just now’,
‘absolute simultaneity’ does not exist: there is no collection of events in the universe which exist ‘now’.
those that are ‘neither-past-nor-future’; these do not form a single instant: they have themselves a duration.”
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