【Mol Cell封面文章 | 张笑天等揭示造血干细胞中存在由多梳蛋白介导的超长程三维基因组互作】DNA甲基化是DNA上重要的化学修饰,主要以CpG甲基化为主。以往的研究揭示了DNA甲基化在胚胎发育和癌症发生过程中的重要作用。但DNA甲基化在近来备受关注的三维基因组的结构上有何作用一直并不清楚。
2020年5月7日,Van Andel研究所张笑天博士,贝勒医学院Erez Lieberman-Aiden 博士,贝勒医学院Margaret Goodell博士合作发表Molecular Cell封面文章。这篇文章揭示了DNA甲基化谷(DNA methylation canyon,DMC)在造血干细胞三维基因组里形成长程空间互作。对Polycomb 蛋白介导的三维基因组研究目前主要集中在胚胎干细胞中进行。本项研究第一次揭示了成体干细胞中存在由Polycomb介导的超长程三维基因组互作。并为DNA甲基化如何参与三维基因组调控提供了全新的视角。值得指出的是DNA甲基化谷主要由DNMT3A与TET2 进行调控,而这两个基因的突变在血液肿瘤和克隆造血中非常频繁,这两个基因的突变是否会造成基因组三维结构的变化,将是非常有趣的研究问题。https://t.cn/A6AWjamN
2020年5月7日,Van Andel研究所张笑天博士,贝勒医学院Erez Lieberman-Aiden 博士,贝勒医学院Margaret Goodell博士合作发表Molecular Cell封面文章。这篇文章揭示了DNA甲基化谷(DNA methylation canyon,DMC)在造血干细胞三维基因组里形成长程空间互作。对Polycomb 蛋白介导的三维基因组研究目前主要集中在胚胎干细胞中进行。本项研究第一次揭示了成体干细胞中存在由Polycomb介导的超长程三维基因组互作。并为DNA甲基化如何参与三维基因组调控提供了全新的视角。值得指出的是DNA甲基化谷主要由DNMT3A与TET2 进行调控,而这两个基因的突变在血液肿瘤和克隆造血中非常频繁,这两个基因的突变是否会造成基因组三维结构的变化,将是非常有趣的研究问题。https://t.cn/A6AWjamN
每年的3·15#国际消费者权益日#都是很重要的一天。但是坚守诚信、保证质量不应只在这一天,正如安利联合创办人之一杰·温安洛先生所言,“没有优质的产品,销售无以为继”。一直以来,安利都严格把控每一件产品的质量,只为消费者带来品质产品,这是我们的承诺,也是责任。
Every year, the 15th of March is when we celebrate #WorldConsumerRightsDay. However, keeping the quality of products high and maintaining our integrity shouldn’t be limited to just this particular day. As Amway’s co-founder, Jay Van Andel said: "It’s difficult to sell anything if you can’t tell people that it works." Amway is always dedicated to maintaining good product quality and delivering them to customers. This is our promise and our responsibility.
Every year, the 15th of March is when we celebrate #WorldConsumerRightsDay. However, keeping the quality of products high and maintaining our integrity shouldn’t be limited to just this particular day. As Amway’s co-founder, Jay Van Andel said: "It’s difficult to sell anything if you can’t tell people that it works." Amway is always dedicated to maintaining good product quality and delivering them to customers. This is our promise and our responsibility.
每年的3·15#国际消费者权益日#都是很重要的一天。但是坚守诚信、保证质量不应只在这一天,正如安利联合创办人之一杰·温安洛先生所言,“没有优质的产品,销售无以为继”。一直以来,安利都严格把控每一件产品的质量,只为消费者带来品质产品,这是我们的承诺,也是责任。
Every year, the 15th of March is when we celebrate #WorldConsumerRightsDay. However, keeping the quality of products high and maintaining our integrity shouldn’t be limited to just this particular day. As Amway’s co-founder, Jay Van Andel said: "It’s difficult to sell anything if you can’t tell people that it works." Amway is always dedicated to maintaining good product quality and delivering them to customers. This is our promise and our responsibility.
Every year, the 15th of March is when we celebrate #WorldConsumerRightsDay. However, keeping the quality of products high and maintaining our integrity shouldn’t be limited to just this particular day. As Amway’s co-founder, Jay Van Andel said: "It’s difficult to sell anything if you can’t tell people that it works." Amway is always dedicated to maintaining good product quality and delivering them to customers. This is our promise and our responsibility.
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