饥饿笼罩加沙
Palestinians gather at food donation point in Rafah
Palestinians have been gathering at a food donation point in Rafah, southern Gaza.
More than half a million people in Gaza are starving due to "woefully insufficient" quantities of food entering the territory since Israel's military responded to Hamas's attack, according to a UN report.
The extent of the population's hunger has eclipsed even the near-famines in Afghanistan and Yemen of recent years, according to figures.
Israel says it is in the final stages of clearing out Hamas militants from northern Gaza, but that months of fighting lie ahead in the south.
news.sky.com/story/israel-gaza-latest-hamas-war-updates-sky-news-blog-12978800?postid=6956602#liveblog-body
Palestinians gather at food donation point in Rafah
Palestinians have been gathering at a food donation point in Rafah, southern Gaza.
More than half a million people in Gaza are starving due to "woefully insufficient" quantities of food entering the territory since Israel's military responded to Hamas's attack, according to a UN report.
The extent of the population's hunger has eclipsed even the near-famines in Afghanistan and Yemen of recent years, according to figures.
Israel says it is in the final stages of clearing out Hamas militants from northern Gaza, but that months of fighting lie ahead in the south.
news.sky.com/story/israel-gaza-latest-hamas-war-updates-sky-news-blog-12978800?postid=6956602#liveblog-body
非核苷类逆转录酶抑制剂（NNRTI）多拉韦林（Doravirine）可长期用于HIV患者的一线治疗——最长至192周！柳叶刀刊登2个III期临床DRIVE-FORWARD和DRIVE-AHEAD的结果，多中心、双盲、随机和活动性比较对照，达标患者为≥18岁、从未接受过治疗、血浆HIV-1 RNA≥1000拷贝/mL和肌酐清除率≥50 mL/分钟；
1. DRIVE-FORWARD在15个国家125个中心，Doravirine（100mg）为试验组，HIV蛋白酶抑制剂ritonavir-第二代蛋白酶抑制剂darunavir组合（100mg/800 mg）为对照组，口服一次/天，配合2个核苷酸或非核苷反转录酶抑制剂（替诺福韦马来酸盐300毫克）和恩曲他滨200mg或阿波卡伟600mg和拉美夫定300 mg；时间是2014.12.01-2020.06.01；
2. DRIVE-AHEAD在23个国家126个中心，Doravirine（100 mg）+拉美夫定（300 mg）+替诺福韦马来酸盐（300 mg）为试验组，依非韦伦 (600mg)+恩曲他滨（200 mg）+替诺福韦马来酸盐（300 mg）为对照，口服1次/天；时间为2015.06.10-2020.08.10；96周双盲试验后有2个选择，进入开放标签延伸doravirine或从对照转到doravirine，再随访96周；（太复杂了）
结果：1494位参与者经历双盲试验后，其中550人继续服用doravirine，502位转换到多拉韦林延伸治疗；继续组的病毒完全抑制率（HIV-1 RNA≤50拷贝/毫升）达83%，转换组的完全抑制率80%；严重副作用均＜1%，脂代谢没问题，体重没增加，肾功损伤几乎没有，无因此退出治疗的；
结论：多拉韦林适用长期一线治疗HIV-1，病毒完全抑制时也可转换至多拉韦林，192周大致3.7年，仍无耐药很不错啦！#微博国际医药##国际创新药闻#
1. DRIVE-FORWARD在15个国家125个中心，Doravirine（100mg）为试验组，HIV蛋白酶抑制剂ritonavir-第二代蛋白酶抑制剂darunavir组合（100mg/800 mg）为对照组，口服一次/天，配合2个核苷酸或非核苷反转录酶抑制剂（替诺福韦马来酸盐300毫克）和恩曲他滨200mg或阿波卡伟600mg和拉美夫定300 mg；时间是2014.12.01-2020.06.01；
2. DRIVE-AHEAD在23个国家126个中心，Doravirine（100 mg）+拉美夫定（300 mg）+替诺福韦马来酸盐（300 mg）为试验组，依非韦伦 (600mg)+恩曲他滨（200 mg）+替诺福韦马来酸盐（300 mg）为对照，口服1次/天；时间为2015.06.10-2020.08.10；96周双盲试验后有2个选择，进入开放标签延伸doravirine或从对照转到doravirine，再随访96周；（太复杂了）
结果：1494位参与者经历双盲试验后，其中550人继续服用doravirine，502位转换到多拉韦林延伸治疗；继续组的病毒完全抑制率（HIV-1 RNA≤50拷贝/毫升）达83%，转换组的完全抑制率80%；严重副作用均＜1%，脂代谢没问题，体重没增加，肾功损伤几乎没有，无因此退出治疗的；
结论：多拉韦林适用长期一线治疗HIV-1，病毒完全抑制时也可转换至多拉韦林，192周大致3.7年，仍无耐药很不错啦！#微博国际医药##国际创新药闻#
#每日一善##四级作文#
英语作文万能句子
1. The main reasons are listed as follows：
主要理由列举如下。
2. I＇m so sorry for not having written to you for such a long time.
十分报歉，很久没有给你写信了。
3. I am a slow walker，but I never walk backwards.
我走得很慢，但是我从来不会后退。
4. People need some courage in life，just like climbing a ough there are stemp ahead，you still fell some timorous and dare not go ahead. But when you conquer the timidity and reach the peak，you will feel the importance of courage as you enjoy the beautiful scenes. It is the same with life.
生需要一点勇气和胆量，就如登一座悬崖峭壁的山峰，虽然上面都有云梯、搭好的台阶，可你就是有点胆怯，不敢向前，但你战胜了自我，到达了顶峰，看到了山顶的景色，你就会感到勇气和胆量是成功的标准人生何尝不是如此呢？
5. Never underestimate your power to change yourself！
永远不要低估你改变自我的能力！
英语作文万能句子
1. The main reasons are listed as follows：
主要理由列举如下。
2. I＇m so sorry for not having written to you for such a long time.
十分报歉，很久没有给你写信了。
3. I am a slow walker，but I never walk backwards.
我走得很慢，但是我从来不会后退。
4. People need some courage in life，just like climbing a ough there are stemp ahead，you still fell some timorous and dare not go ahead. But when you conquer the timidity and reach the peak，you will feel the importance of courage as you enjoy the beautiful scenes. It is the same with life.
生需要一点勇气和胆量，就如登一座悬崖峭壁的山峰，虽然上面都有云梯、搭好的台阶，可你就是有点胆怯，不敢向前，但你战胜了自我，到达了顶峰，看到了山顶的景色，你就会感到勇气和胆量是成功的标准人生何尝不是如此呢？
5. Never underestimate your power to change yourself！
永远不要低估你改变自我的能力！
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