OPRA Trial
Ph2 trial w/ random to induction CTH followed by CRT （INCT-CRT） or vice versa（CRT-CNCT）
Stage II（T3-4, N0）/III（any T, N1-2） rectal cancer
cCR/nCR were offered WW, iCR were recommended TME
: DFS
: TME-free survival（Organ preservation）
RESULTS
324 pts, median FU 5.1 y
3-y DFS rates: INCT-CRT 76%，CRT-CNCT 76% （no sig）
5-y DFS rates: INCT-CRT 71%，CRT-CNCT 69%（no sig）
An improvement in DFS among patients treated with TNT and selective WW compared with historical controls was not met
cN1+ on baseline MRI was the only variable associated with DFS
TME-free survival: INCT-CRT 39%, CRT-CNCT 54% (P = 0.012)
5-y OS rates: INCT-CRT 88%，CRT-CNCT 85%（no sig）
5-y LRFS rates: INCT-CRT 94%，CRT-CNCT 90%（no sig）
5-y DMFS rates: INCT-CRT 80%，CRT-CNCT 78%（no sig）
94% of regrowth within 2 y, 99% within 3 y，patients with rectal cancer offered WW after neoadjuvant therapy should have very close surveillance during the first 3 years.
5-y organ preservation rates: INCT-CRT 39%，CRT-CNCT 54%（P = .012）
DFS similar for TME post-restaging and WW followed by TME post-regrowth (both 64%, no sig)
Distant metastasis similar for TME post-restaging and WW followed by TME post-regrowth
~10% had a pCR
3-y OP rates：cCR 77%，nCR 40% (P < .001).
3-y DFS rates：cCR 88%，nCR 69% ，iCR：56% (P < .001)
Clinical tumor response grade was associated with DFS, LRFS, DMFS, and OS.
目前感觉TNT模式的优势就是保留器官，提高生活质量。
Ph2 trial w/ random to induction CTH followed by CRT （INCT-CRT） or vice versa（CRT-CNCT）
Stage II（T3-4, N0）/III（any T, N1-2） rectal cancer
cCR/nCR were offered WW, iCR were recommended TME
: DFS
: TME-free survival（Organ preservation）
RESULTS
324 pts, median FU 5.1 y
3-y DFS rates: INCT-CRT 76%，CRT-CNCT 76% （no sig）
5-y DFS rates: INCT-CRT 71%，CRT-CNCT 69%（no sig）
An improvement in DFS among patients treated with TNT and selective WW compared with historical controls was not met
cN1+ on baseline MRI was the only variable associated with DFS
TME-free survival: INCT-CRT 39%, CRT-CNCT 54% (P = 0.012)
5-y OS rates: INCT-CRT 88%，CRT-CNCT 85%（no sig）
5-y LRFS rates: INCT-CRT 94%，CRT-CNCT 90%（no sig）
5-y DMFS rates: INCT-CRT 80%，CRT-CNCT 78%（no sig）
94% of regrowth within 2 y, 99% within 3 y，patients with rectal cancer offered WW after neoadjuvant therapy should have very close surveillance during the first 3 years.
5-y organ preservation rates: INCT-CRT 39%，CRT-CNCT 54%（P = .012）
DFS similar for TME post-restaging and WW followed by TME post-regrowth (both 64%, no sig)
Distant metastasis similar for TME post-restaging and WW followed by TME post-regrowth
~10% had a pCR
3-y OP rates：cCR 77%，nCR 40% (P < .001).
3-y DFS rates：cCR 88%，nCR 69% ，iCR：56% (P < .001)
Clinical tumor response grade was associated with DFS, LRFS, DMFS, and OS.
目前感觉TNT模式的优势就是保留器官，提高生活质量。
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亲爱的朋友们，春节期间成都W酒店将对部分门店营业时间做出如下调整，详情请见海报。
带来不便敬请谅解！
祝您新年快乐，龙年大吉！
Kindly Reminder：
Dear W friends. Please note that W Chengdu will make the following adjustments to the operating hours during the New Year period.
We apologise for any inconvenience caused!
Wish you a happy new year. ALL SPRING LONG！
亲爱的朋友们，春节期间成都W酒店将对部分门店营业时间做出如下调整，详情请见海报。
带来不便敬请谅解！
祝您新年快乐，龙年大吉！
Kindly Reminder：
Dear W friends. Please note that W Chengdu will make the following adjustments to the operating hours during the New Year period.
We apologise for any inconvenience caused!
Wish you a happy new year. ALL SPRING LONG！
前总统没有豁免权，他又输了一场官司。
“For the purpose of this criminal case, former President has become a citizen, with all of the defenses of any other criminal defendant. But any executive immunity that may have protected him while he served as President no longer protects him against this prosecution,” the court wrote.
The ruling from the three-judge panel was unanimous. The three-judge panel who issued the ruling Tuesday includes two judges, J. Michelle Childs and Florence Pan, who were appointed by Joe Biden and one, Karen LeCraft Henderson, who was appointed by George H.W. Bush.
“For the purpose of this criminal case, former President has become a citizen, with all of the defenses of any other criminal defendant. But any executive immunity that may have protected him while he served as President no longer protects him against this prosecution,” the court wrote.
The ruling from the three-judge panel was unanimous. The three-judge panel who issued the ruling Tuesday includes two judges, J. Michelle Childs and Florence Pan, who were appointed by Joe Biden and one, Karen LeCraft Henderson, who was appointed by George H.W. Bush.
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